We explore the mysteries of the cell sigalling through biophysics/ biochemsitry/physical chemistry. Membrane protein is of our interest as 60% of drug targets are located at the cell surface.
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2024/6/26
賀! 恭喜碩班學生林喆凱獲得清大化學研究生壁報佳作獎!
2024/3/24
歡迎2024碩班新生林秉定，郭晉儒，陳隆凱，翁維聰加入!
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2024/1/17
賀! 恭喜博士班學生白茹瑄獲頒國家科學及技術委員會"博士班獎學金"!
2023/12/15
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We are hiring!
PhD , graudate students, university students positions are opening! feel free to contact with me!
Email: chunweilin@mx.nthu.edu.tw
Our research
Signal transduction dictates the fate of the cell by activating different cellular functions including differentiation, and proliferation. Different types of cancers indicate that certain mutations that occurred on signaling proteins disrupt the corresponding downstream signaling in the cancer cell . In addition, the high activation due to the overexpression of the receptor in signaling is often associated with certain types of cancers. Hence, more research targeting the detailed mechanisms in the signaling process should help us understand the origin of aberrant signal transduction and develop the corresponding medical treatment for the cancers.
Reconstitution of protein in the Supported lipid bilayer
purify proteins for in-vitro reconstitution experiments to target at complicated system with more flexibility.
Study the membrane protein directly on the live cell.
Incorporate the live cell into the experiments to be more close to the biological system.
Newly discovered phase transition
Use the newly discovered phase transition (protein condensation in the living system as the amplifying factor to study the subtle protein-protein
interactions on the membrane.
Single molecule TIRF microscopy
The powerful platform to instantaneously monitor single molecular interactions on the lipid layers and the cell with both the spatial resolution and the time resolution.
